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Cardiac troponin and tropomyosin bind to F‐actin cooperatively, as revealed by fluorescence microscopy

In cardiac muscle, binding of troponin (Tn) and tropomyosin (Tpm) to filamentous (F)‐actin forms thin filaments capable of Ca(2+)‐dependent regulation of contraction. Tpm binds to F‐actin in a head‐to‐tail fashion, while Tn stabilizes these linkages. Valuable structural and functional information ha...

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Bibliographic Details
Published in:FEBS Open Bio
Main Authors: Solís, Christopher, Robinson, John M.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7327902/
https://ncbi.nlm.nih.gov/pubmed/32385956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/2211-5463.12876
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