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Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations.

The finding of G-->A hypermutated retroviral genomes in which up to 40% of guanines may be substituted by adenines was proposed to result from the depletion of the intracellular dCTP concentration and suggested a means to hypermutagenize nucleic acids. Using a RNA/reverse transcriptase ratio of a...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Martinez, M A, Vartanian, J P, Wain-Hobson, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC45320/
https://ncbi.nlm.nih.gov/pubmed/7527543
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