Hypermutagenesis of RNA using human immunodeficiency virus type 1 reverse transcriptase and biased dNTP concentrations.

The finding of G-->A hypermutated retroviral genomes in which up to 40% of guanines may be substituted by adenines was proposed to result from the depletion of the intracellular dCTP concentration and suggested a means to hypermutagenize nucleic acids. Using a RNA/reverse transcriptase ratio of appr...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Martinez, M A, Vartanian, J P, Wain-Hobson, S
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1994
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45320/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7527543/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.11787
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