Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptase.

We have purified and determined functional parameters of reconstituted, recombinant HIV-1 reverse transcriptase (RT) heterodimers within which either the p66 or p51 polypeptide was selectively mutated in one or both aspartic acid residues constituting the proposed polymerase active site (-Y-M-D-D-)....

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Publicat a:EMBO J
Autors principals: Le Grice, S F, Naas, T, Wohlgensinger, B, Schatz, O
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1991
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC453128/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1718745/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb04960.x
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