Coordinate loss of MAP3K7 and CHD1 promotes aggressive prostate cancer

Prostate cancer (CaP) subtypes are poorly defined and functional validation of drivers of ETS rearrangement-negative CaP has not been conducted. Here, we identified an ETS(−) subtype of aggressive CaP (ERG(−)MAP3K7(del)CHD1(del)) and used a novel developmental model and a cell line xenograft model t...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Rodrigues, Lindsey Ulkus, Rider, Leah, Nieto, Cera, Romero, Lina, Karimpour-Fard, Anis, Loda, Massimo, Lucia, M. Scott, Wu, Min, Shi, Lihong, Cimic, Adela, Sirintrapun, S. Joseph, Nolley, Rosalie, Pac, Colton, Chen, Haitao, Peehl, Donna M., Xu, Jianfeng, Liu, Wennuan, Costello, James C., Cramer, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531265/
https://ncbi.nlm.nih.gov/pubmed/25770290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-1596
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