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Intersecting transcription networks constrain gene regulatory evolution

Epistasis—the non-additive interactions between different genetic loci—constrains evolutionary pathways, blocking some and permitting others(1–8). For biological networks such as transcription circuits, the nature of these constraints and their consequences are largely unknown. Here we describe the...

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Publicado en:Nature
Autores principales: Sorrells, Trevor R, Booth, Lauren N, Tuch, Brian B, Johnson, Alexander D
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531262/
https://ncbi.nlm.nih.gov/pubmed/26153861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14613
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