The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation

To maintain bone mass turnover and bone mineral density (BMD), bone marrow (BM) mesenchymal stem cells (MSCs) are constantly recruited and subsequently differentiated into osteoblasts. HIV-infected patients present lower BMD than non-HIV infected individuals and a higher prevalence of osteopenia/ost...

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Dettagli Bibliografici
Pubblicato in:Aging Cell
Autori principali: Beaupere, Carine, Garcia, Marie, Larghero, Jerome, Fève, Bruno, Capeau, Jacqueline, Lagathu, Claire
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Ltd 2015
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531068/
https://ncbi.nlm.nih.gov/pubmed/25847297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.12308
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