pH-Responsive therapeutic solid lipid nanoparticles for reducing P-glycoprotein-mediated drug efflux of multidrug resistant cancer cells

In this study, a novel pH-responsive cholesterol-PEG adduct-coated solid lipid nanoparticles (C-PEG-SLNs) carrying doxorubicin (DOX) capable of overcoming multidrug resistance (MDR) breast cancer cells is presented. The DOX-loaded SLNs have a mean hydrodynamic diameter of ~100 nm and a low polydispe...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Chen, Hsin-Hung, Huang, Wen-Chia, Chiang, Wen-Hsuan, Liu, Te-I, Shen, Ming-Yin, Hsu, Yuan-Hung, Lin, Sung-Chyr, Chiu, Hsin-Cheng
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531030/
https://ncbi.nlm.nih.gov/pubmed/26346762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S86053
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