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The Prostaglandin Transporter: Eicosanoid Reuptake, Control of Signaling, and Development of High-Affinity Inhibitors as Drug Candidates

We discovered the prostaglandin transporter (PGT) and cloned the human cDNA and gene. PGT transports extracellular prostaglandins (PGs) into the cytoplasm for enzymatic inactivation. PGT knockout mice have elevated prostaglandin E(2) (PGE(2)) and neonatal patent ductus arteriosus, which reflects PGT...

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Detalhes bibliográficos
Publicado no:Trans Am Clin Climatol Assoc
Main Authors: Schuster, Victor L., Chi, Yuling, Lu, Run
Formato: Artigo
Idioma:Inglês
Publicado em: American Clinical and Climatological Association 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530674/
https://ncbi.nlm.nih.gov/pubmed/26330684
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