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Failure of post-natal ductus arteriosus closure in prostaglandin transporter-deficient mice: Patent Ductus Arteriosus & Prostaglandin Transporter

BACKGROUND: Prostaglandin E(2) (PGE(2)) plays a major role both in maintaining patency of the fetal ductus arteriosus (DA) and in closure of the DA after birth. The rate- limiting step in PGE(2) signal termination is PGE(2) uptake by the transporter PGT. METHODS AND RESULTS: To determine the role of...

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Autors principals: Chang, Hee-Yoon, Locker, Joseph, Lu, Run, Schuster, Victor L.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836805/
https://ncbi.nlm.nih.gov/pubmed/20083684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.862946
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