STIL binding to Polo-box 3 of PLK4 regulates centriole duplication

Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication. Here, we demonstrate that the SCL/TAL1 interrupting locus (STIL) protein interacts via its coiled-coil region (STIL-CC) with PLK4 in vivo. STIL-C...

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Bibliographic Details
Published in:eLife
Main Authors: Arquint, Christian, Gabryjonczyk, Anna-Maria, Imseng, Stefan, Böhm, Raphael, Sauer, Evelyn, Hiller, Sebastian, Nigg, Erich A, Maier, Timm
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530586/
https://ncbi.nlm.nih.gov/pubmed/26188084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07888
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