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DNA sequencing with MspA: Molecular Dynamics simulations reveal free-energy differences between sequencing and non-sequencing mutants

MspA has been identified as a promising candidate protein as a component of a nanopore-based DNA-sequencing device. However the wildtype protein must be engineered to incorporate all of the features desirable for an accurate and efficient device. In the present study we have utilized atomistic molec...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Manara, Richard M.A., Jayne Wallace, E., Khalid, Syma
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530457/
https://ncbi.nlm.nih.gov/pubmed/26255609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12783
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