Activation of AMP-Activated Protein Kinase Prevents TGF-β1–Induced Epithelial-Mesenchymal Transition and Myofibroblast Activation

Transforming growth factor (TGF)-β contributes to tubulointerstitial fibrosis. We investigated the mechanism by which TGF-β exerts its profibrotic effects and specifically the role of AMP-activated protein kinase (AMPK) in kidney tubular epithelial cells and interstitial fibroblasts. In proximal tub...

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Detalhes bibliográficos
Publicado no:Am J Pathol
Main Authors: Thakur, Sachin, Viswanadhapalli, Suryavathi, Kopp, Jeffrey B., Shi, Qian, Barnes, Jeffrey L., Block, Karen, Gorin, Yves, Abboud, Hanna E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2015
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530134/
https://ncbi.nlm.nih.gov/pubmed/26071397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2015.04.014
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