Cysteine oxidation impairs systemic glucocorticoid responsiveness in children with difficult-to-treat asthma

BACKGROUND: The mechanisms underlying glucocorticoid responsiveness are largely unknown. Although redox regulation of the glucocorticoid receptor (GR) has been reported, it has not been studied in asthma. OBJECTIVE: We characterized systemic cysteine oxidation and its association with inflammatory a...

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Bibliographic Details
Published in:J Allergy Clin Immunol
Main Authors: Stephenson, Susan T., Brown, Lou Ann S., Helms, My N., Qu, Hongyan, Brown, Sheena D., Brown, Milton R., Fitzpatrick, Anne M.
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530082/
https://ncbi.nlm.nih.gov/pubmed/25748343
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaci.2015.01.023
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