Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus.

In HeLa cells, RNA polymerase III (pol III)-mediated transcription is severely inhibited by poliovirus infection. This is due primarily to a reduction in the transcriptional activity of TFIIIC, a transcription factor which binds in a sequence specific manner to the internal promoter of pol III genes...

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Pubblicato in:	EMBO J
Autori principali:	Clark, M E, Hämmerle, T, Wimmer, E, Dasgupta, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1991
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC453008/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1915271/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb07844.x
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