Poliovirus proteinase 3C converts an active form of transcription factor IIIC to an inactive form: a mechanism for inhibition of host cell polymerase III transcription by poliovirus.

In HeLa cells, RNA polymerase III (pol III)-mediated transcription is severely inhibited by poliovirus infection. This is due primarily to a reduction in the transcriptional activity of TFIIIC, a transcription factor which binds in a sequence specific manner to the internal promoter of pol III genes...

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Detalles Bibliográficos
Main Authors: Clark, M E, Hämmerle, T, Wimmer, E, Dasgupta, A
Formato: Artigo
Idioma:Inglês
Publicado: 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC453008/
https://ncbi.nlm.nih.gov/pubmed/1915271
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