Peripherally induced tolerance depends on pTreg cells that require Hopx to inhibit intrinsic IL-2 expression

Dendritic Cells (DCs) can induce peripheral immune tolerance that prevents autoimmune responses. Antigen presentation by peripheral DCs under steady state conditions leads to a conversion of some peripheral CD4(+) T cells into Treg cells that require Homeodomain Only Protein (Hopx) to mediate T cell...

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Udgivet i:J Immunol
Main Authors: Jones, Andrew, Opejin, Adeleye, Henderson, Jacob G., Gross, Cindy, Jain, Rajan, Epstein, Jonathan A., Flavell, Richard A., Hawiger, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530038/
https://ncbi.nlm.nih.gov/pubmed/26170384
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500174
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