H3K9 Trimethylation Silences Fas Expression to Confer Colon Carcinoma Immune Escape and 5-Fluorouracil Chemoresistance

The Fas-FasL effector mechanism plays a key role in cancer immune surveillance by host T cells, but metastatic human colon carcinoma often uses silencing Fas expression as a mechanism of immune evasion. The molecular mechanism under FAS transcriptional silencing in human colon carcinoma is unknown....

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Paschall, Amy V., Yang, Dafeng, Lu, Chunwan, Choi, Jeong-Hyeon, Li, Xia, Liu, Feiyan, Figueroa, Mario, Oberlies, Nicholas H., Pearce, Cedric, Bollag, Wendy B., Nayak-Kapoor, Asha, Liu, Kebin
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530033/
https://ncbi.nlm.nih.gov/pubmed/26136424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402243
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