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Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells
Recall responses by memory CD8 T cells are impaired in the absence of CD4 T cells. Although several mechanisms have been proposed, the molecular basis is still largely unknown. Using a local influenza virus infection in the respiratory tract and the lung of CD4(−/−) mice, we show that memory CD8 T c...
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| Опубликовано в: : | J Immunol |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4530017/ https://ncbi.nlm.nih.gov/pubmed/26163589 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500451 |
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