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Persistent Antigen and Prolonged AKT-mTORC1 Activation Underlie Memory CD8 T Cell Impairment in the Absence of CD4 T Cells

Recall responses by memory CD8 T cells are impaired in the absence of CD4 T cells. Although several mechanisms have been proposed, the molecular basis is still largely unknown. Using a local influenza virus infection in the respiratory tract and the lung of CD4(−/−) mice, we show that memory CD8 T c...

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Bibliografski detalji
Izdano u:J Immunol
Glavni autori: Li, Yingzhong, Shen, Chase, Zhu, Bingdong, Shi, Feng, Eisen, Herman N., Chen, Jianzhu
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4530017/
https://ncbi.nlm.nih.gov/pubmed/26163589
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1500451
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