GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells

The malignant phenotype of chronic myeloid leukemia (CML) is due to the abnormal tyrosine kinase activity of the BCR-ABL oncoprotein, which signals several downstream cell survival pathways, including phosphoinositide 3-kinase/AKT, signal transducer and activator of transcription 5 and extracellular...

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Detalhes bibliográficos
Main Authors: Joha, S, Nugues, A-L, Hétuin, D, Berthon, C, Dezitter, X, Dauphin, V, Mahon, F-X, Roche-Lestienne, C, Preudhomme, C, Quesnel, B, Idziorek, T
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3312406/
https://ncbi.nlm.nih.gov/pubmed/21804606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.328
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