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Efficient, large-scale synthesis and preclinical studies of MRS5698, a highly selective A(3) adenosine receptor agonist that protects against chronic neuropathic pain
We reported that 2-(3,4-difluorophenylethynyl)-N(6)-3-chlorobenzyl (N)-methanocarba adenosine derivative 1 (MRS5698) binds selectively to human and mouse A(3) adenosine receptors (A(3)ARs, K(i) 3 nM). It is becoming an important pharmacological tool for defining A(3)AR effects and is orally active i...
Shranjeno v:
| izdano v: | Purinergic Signal |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Springer Netherlands
2015
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4529848/ https://ncbi.nlm.nih.gov/pubmed/26111639 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-015-9459-2 |
| Oznake: |
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