The PI3K/Akt Pathway Regulates Oxygen Metabolism via Pyruvate Dehydrogenase (PDH)-E1α Phosphorylation

Inhibition of the PI3K/Akt pathway decreases hypoxia within SQ20B human head and neck cancer xenografts. We set out to understand the molecular mechanism underlying this observation. We measured oxygen consumption using both a Clark electrode and an extracellular flux analyzer. We made these measure...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Cerniglia, George J., Dey, Souvik, Gallagher-Colombo, Shannon M., Daurio, Natalie A, Tuttle, Stephen, Busch, Theresa M., Lin, Alexander, Sun, Ramon, Esipova, Tatiana V., Vinogradov, Sergei A., Denko, Nicholas, Koumenis, Constantinos, Maity, Amit
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529780/
https://ncbi.nlm.nih.gov/pubmed/25995437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-14-0888
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