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Structural basis for the RING catalyzed synthesis of K63 linked ubiquitin chains

The RING E3 ligase catalysed formation of lysine 63 linked ubiquitin chains by the Ube2V2–Ubc13 E2 complex is required for many important biological processes. Here we report the structure of the RING domain dimer of rat RNF4 in complex with a human Ubc13~Ub conjugate and Ube2V2. The structure has c...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Branigan, Emma, Plechanovová, Anna, Jaffray, Ellis, Naismith, James H., Hay, Ronald T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529489/
https://ncbi.nlm.nih.gov/pubmed/26148049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3052
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