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Ubiquitin transfer by a RING E3 ligase occurs from a closed E2~ubiquitin conformation
Based on extensive structural analysis it was proposed that RING E3 ligases prime the E2~ubiquitin conjugate (E2~Ub) for catalysis by locking it into a closed conformation, where ubiquitin is folded back onto the E2 exposing the restrained thioester bond to attack by substrate nucleophile. However t...
Salvato in:
| Pubblicato in: | Nat Commun |
|---|---|
| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group UK
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7275055/ https://ncbi.nlm.nih.gov/pubmed/32503993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16666-y |
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