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Structural model of ubiquitin transfer onto an artificial RING finger as an E3 ligase
The artificial WSTF PHD_EL5 RING finger was designed via “α-helical region substitution”, and its structural model for the attachment of activated ubiquitin has been demonstrated. Chemical modifications of Cys residues, the circular dichroism spectra, and substrate-independent ubiquitination assays...
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| Autor principal: | |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4192618/ https://ncbi.nlm.nih.gov/pubmed/25300604 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06574 |
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