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Unstirred Water Layers and the Kinetics of Organic Cation Transport

PURPOSE: Unstirred water layers (UWLs) present an unavoidable complication in the measurement of transport kinetics in cultured cells and the high rates of transport achieved by overexpressing heterologous transporters exacerbate the UWL effect. This study examined the correlation between measured J...

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Dettagli Bibliografici
Pubblicato in:Pharm Res
Autori principali: Shibayama, Takahiro, Morales, Mark, Zhang, Xiaohong, Martinez, Lucy, Berteloot, Alfred, Secomb, Timothy W., Wright, Stephen H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529401/
https://ncbi.nlm.nih.gov/pubmed/25791216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1675-5
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