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Unstirred Water Layers and the Kinetics of Organic Cation Transport

PURPOSE: Unstirred water layers (UWLs) present an unavoidable complication in the measurement of transport kinetics in cultured cells and the high rates of transport achieved by overexpressing heterologous transporters exacerbate the UWL effect. This study examined the correlation between measured J...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Shibayama, Takahiro, Morales, Mark, Zhang, Xiaohong, Martinez, Lucy, Berteloot, Alfred, Secomb, Timothy W., Wright, Stephen H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529401/
https://ncbi.nlm.nih.gov/pubmed/25791216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1675-5
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