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Unstirred Water Layers and the Kinetics of Organic Cation Transport

PURPOSE: Unstirred water layers (UWLs) present an unavoidable complication in the measurement of transport kinetics in cultured cells and the high rates of transport achieved by overexpressing heterologous transporters exacerbate the UWL effect. This study examined the correlation between measured J...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Pharm Res
Hauptverfasser: Shibayama, Takahiro, Morales, Mark, Zhang, Xiaohong, Martinez, Lucy, Berteloot, Alfred, Secomb, Timothy W., Wright, Stephen H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529401/
https://ncbi.nlm.nih.gov/pubmed/25791216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-015-1675-5
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