Activity of second-generation ALK inhibitors against crizotinib-resistant mutants in an NPM-ALK model compared to EML4-ALK

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase receptor involved in both solid and hematological tumors. About 80% of ALK-positive anaplastic large-cell lymphoma (ALCL) cases are characterized by the t(2;5)(p23;q35) translocation, encoding for the aberrant fusion protein nucleophosmin (NPM)-A...

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Bibliographic Details
Published in:Cancer Med
Main Authors: Fontana, Diletta, Ceccon, Monica, Gambacorti-Passerini, Carlo, Mologni, Luca
Format: Artigo
Language:Inglês
Published: John Wiley & Sons, Ltd 2015
Subjects:
Clinical Cancer Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529334/
https://ncbi.nlm.nih.gov/pubmed/25727400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.413
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