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Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies

The cyclin-dependent kinase 4 (CDK4)-cyclin D1 complex plays a crucial role in the transition from the G1 phase to S phase of the cell cycle. Among the CDKs, CDK4 is one of the genes most frequently affected by somatic genetic variations that are associated with various forms of cancer. Thus, becaus...

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Podrobná bibliografie
Vydáno v:PLoS One
Hlavní autoři: N, Nagasundaram, Zhu, Hailong, Liu, Jiming, V, Karthick, C, George Priya Doss, Chakraborty, Chiranjib, Chen, Luonan
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529227/
https://ncbi.nlm.nih.gov/pubmed/26252490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133969
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