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Analysing the Effect of Mutation on Protein Function and Discovering Potential Inhibitors of CDK4: Molecular Modelling and Dynamics Studies

The cyclin-dependent kinase 4 (CDK4)-cyclin D1 complex plays a crucial role in the transition from the G1 phase to S phase of the cell cycle. Among the CDKs, CDK4 is one of the genes most frequently affected by somatic genetic variations that are associated with various forms of cancer. Thus, becaus...

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Publicat a:PLoS One
Autors principals: N, Nagasundaram, Zhu, Hailong, Liu, Jiming, V, Karthick, C, George Priya Doss, Chakraborty, Chiranjib, Chen, Luonan
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529227/
https://ncbi.nlm.nih.gov/pubmed/26252490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0133969
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