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Structural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors
Some individuals with non-small-cell lung cancer (NSCLC) benefit from therapies targeting epidermal growth factor receptor (EGFR), and the characterization of a new mechanism of resistance to the EGFR-specific antibody gefitinib will provide valuable insight into how therapeutic strategies might be...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4121614/ https://ncbi.nlm.nih.gov/pubmed/25091415 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05868 |
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