Structural signature of the G719S-T790M double mutation in the EGFR kinase domain and its response to inhibitors

Some individuals with non-small-cell lung cancer (NSCLC) benefit from therapies targeting epidermal growth factor receptor (EGFR), and the characterization of a new mechanism of resistance to the EGFR-specific antibody gefitinib will provide valuable insight into how therapeutic strategies might be...

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Autores principales: C., George Priya Doss, B., Rajith, Chakraborty, Chiranjib, N., NagaSundaram, Ali, Shabana Kouser, Zhu, Hailong
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121614/
https://ncbi.nlm.nih.gov/pubmed/25091415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep05868
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