Microstructural White Matter Properties Mediate the Association between APOE and Perceptual Speed in Very Old Persons without Dementia

BACKGROUND: Reduced white matter integrity, as indicated by lower fractional anisotropy (FA) and higher mean diffusivity (MD), has been related to poorer perceptual speed (PS) performance. As the ε4 allele has been associated with lower white matter integrity in old age, this represents a potential...

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Veröffentlicht in:PLoS One
Hauptverfasser: Laukka, Erika J., Lövdén, Martin, Kalpouzos, Grégoria, Papenberg, Goran, Keller, Lina, Graff, Caroline, Li, Tie-Qiang, Fratiglioni, Laura, Bäckman, Lars
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529164/
https://ncbi.nlm.nih.gov/pubmed/26252210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134766
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