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A small molecule inhibitor of p53 stimulates amplification of hematopoietic stem cells but does not promote tumor development in mice

It has been shown that genetic inhibition of p53 leads to enhanced proliferation of hematopoietic stem cells (HSCs). This could, in theory, contribute to the increased frequency of tumor development observed in p53-defcient mice and humans. In our previous work, we identified chemical p53 inhibitors...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Leonova, Katerina I., Shneyder, Jelena O., Antoch, Marina P., Toshkov, Illia A., Novototskaya, Liliya R., Komarov, Pavel G., Komarova, Elena A., Gudkov, Andrei V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4529072/
https://ncbi.nlm.nih.gov/pubmed/20404530
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