Somatic hypermutation of immunoglobulin kappa may depend on sequences 3' of C kappa and occurs on passenger transgenes.

We have compared the pattern of somatic mutation in different immunoglobulin kappa transgenes and suggest that an element(s) located between 1 kb and 9 kb 3' of C kappa is necessary for somatic hypermutation of the antibody V gene. The sequences of transgenic and endogenous Ig V regions were determi...

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Publié dans:	EMBO J
Auteurs principaux:	Sharpe, M J, Milstein, C, Jarvis, J M, Neuberger, M S
Format:	Artigo
Langue:	Inglês
Publié:	Nature Publishing Group 1991
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452901/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1905999/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb07748.x
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