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Structure of the human MLH1 N-terminus: implications for predisposition to Lynch syndrome

Mismatch repair prevents the accumulation of erroneous insertions/deletions and non-Watson–Crick base pairs in the genome. Pathogenic mutations in the MLH1 gene are associated with a predisposition to Lynch and Turcot’s syndromes. Although genetic testing for these mutations is available, robust cla...

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Detalhes bibliográficos
Publicado no:Acta Crystallogr F Struct Biol Commun
Main Authors: Wu, Hong, Zeng, Hong, Lam, Robert, Tempel, Wolfram, Kerr, Iain D., Min, Jinrong
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528928/
https://ncbi.nlm.nih.gov/pubmed/26249686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X15010183
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