Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

The neu/HER2 proto-oncogene encodes a transmembrane tyrosine kinase homologous to receptors for polypeptide growth factors. The oncogenic potential for the presumed receptor is released through multiple genetic mechanisms including a specific point mutation, truncation at the extracellular domain an...

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Detalles Bibliográficos
Publicado en:EMBO J
Main Authors: Peles, E, Levy, R B, Or, E, Ullrich, A, Yarden, Y
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1991
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC452891/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1676673/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1991.tb07739.x
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