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A single autophosphorylation site confers oncogenicity to the Neu/ErbB-2 receptor and enables coupling to the MAP kinase pathway.

The transforming potential of the Neu/ErbB-2 receptor tyrosine kinase undergoes inactivation by deletion of the non-catalytic C-terminal tail, which contains five autophosphorylation sites. To determine which site is essential for oncogenicity, we tailed the C-terminally-deleted mutant with individu...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Ben-Levy, R, Paterson, H F, Marshall, C J, Yarden, Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1994
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC395227/
https://ncbi.nlm.nih.gov/pubmed/7913890
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