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Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase C gamma.

The neu/HER2 proto-oncogene encodes a transmembrane tyrosine kinase homologous to receptors for polypeptide growth factors. The oncogenic potential for the presumed receptor is released through multiple genetic mechanisms including a specific point mutation, truncation at the extracellular domain an...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Peles, E, Levy, R B, Or, E, Ullrich, A, Yarden, Y
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1991
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC452891/
https://ncbi.nlm.nih.gov/pubmed/1676673
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