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A Mutation in Caenorhabditis elegans NDUF-7 Activates the Mitochondrial Stress Response and Prolongs Lifespan via ROS and CED-4

The mevalonate pathway is responsible for the synthesis of cholesterol, coenzyme Q, and prenyl groups essential for small GTPase modification and function, and for the production of dolichols important for protein glycosylation. Statins, i.e., cholesterol-lowering drugs that inhibit the rate-limitin...

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Bibliografiske detaljer
Udgivet i:G3 (Bethesda)
Main Authors: Rauthan, Manish, Ranji, Parmida, Abukar, Ragda, Pilon, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Genetics Society of America 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528320/
https://ncbi.nlm.nih.gov/pubmed/26038366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/g3.115.018598
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