Heat shock protein 90 inhibition abrogates TLR4-mediated NF-κB activity and reduces renal ischemia-reperfusion injury

Renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury. Toll-like receptor 4 (TLR4) mediates sterile inflammation following renal IRI. Heat shock protein 90 (Hsp90) inhibition is a potential strategy to reduce IRI, and AT13387 is a novel Hsp90 inhibitor with low toxicity. T...

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Publicado no:Sci Rep
Main Authors: O’Neill, Stephen, Humphries, Duncan, Tse, George, Marson, Lorna P., Dhaliwal, Kevin, Hughes, Jeremy, Ross, James A., Wigmore, Stephen J, Harrison, Ewen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528191/
https://ncbi.nlm.nih.gov/pubmed/26248657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep12958
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