TLR4 activation mediates kidney ischemia/reperfusion injury

Ischemia/reperfusion injury (IRI) may activate innate immunity through the engagement of TLRs by endogenous ligands. TLR4 expressed within the kidney is a potential mediator of innate activation and inflammation. Using a mouse model of kidney IRI, we demonstrated a significant increase in TLR4 expre...

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Bibliographic Details
Main Authors: Wu, Huiling, Chen, Gang, Wyburn, Kate R., Yin, Jianlin, Bertolino, Patrick, Eris, Josette M., Alexander, Stephen I., Sharland, Alexandra F., Chadban, Steven J.
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2007
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1974864/
https://ncbi.nlm.nih.gov/pubmed/17853945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI31008
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