Intramolecular Binding of the Rad9 C Terminus in the Checkpoint Clamp Rad9-Hus1-Rad1 Is Closely Linked with Its DNA Binding

The human checkpoint clamp Rad9-Hus1-Rad1 (9-1-1) is loaded onto chromatin by its loader complex, Rad17-RFC, following DNA damage. The 120-amino acid (aa) stretch of the Rad9 C terminus (C-tail) is unstructured and projects from the core ring structure (CRS). Recent studies showed that 9-1-1 and CRS...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Takeishi, Yukimasa, Iwaya-Omi, Rie, Ohashi, Eiji, Tsurimoto, Toshiki
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528151/
https://ncbi.nlm.nih.gov/pubmed/26088138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.669002
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