A New Approach to Produce HIV-1 Envelope Trimers: BOTH CLEAVAGE AND PROPER GLYCOSYLATION ARE ESSENTIAL TO GENERATE AUTHENTIC TRIMERS

The trimeric envelope spike of HIV-1 mediates virus entry into human cells. The exposed part of the trimer, gp140, consists of two noncovalently associated subunits, gp120 and gp41 ectodomain. A recombinant vaccine that mimics the native trimer might elicit entry-blocking antibodies and prevent viru...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: AlSalmi, Wadad, Mahalingam, Marthandan, Ananthaswamy, Neeti, Hamlin, Christopher, Flores, Dalia, Gao, Guofen, Rao, Venigalla B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Membrane Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528139/
https://ncbi.nlm.nih.gov/pubmed/26088135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.656611
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