Response Element Composition Governs Correlations between Binding Site Affinity and Transcription in Glucocorticoid Receptor Feed-forward Loops

Combinatorial gene regulation through feed-forward loops (FFLs) can bestow specificity and temporal control to client gene expression; however, characteristics of binding sites that mediate these effects are not established. We previously showed that the glucocorticoid receptor (GR) and KLF15 form c...

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Vydáno v:J Biol Chem
Hlavní autoři: Sasse, Sarah K., Zuo, Zheng, Kadiyala, Vineela, Zhang, Liyang, Pufall, Miles A., Jain, Mukesh K., Phang, Tzu L., Stormo, Gary D., Gerber, Anthony N.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4528137/
https://ncbi.nlm.nih.gov/pubmed/26088140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.668558
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