Co-occurring genomic alterations define major subsets of KRAS - mutant lung adenocarcinoma with distinct biology, immune profiles, and therapeutic vulnerabilities

The molecular underpinnings that drive the heterogeneity of KRAS-mutant lung adenocarcinoma (LUAC) are poorly characterized. We performed an integrative analysis of genomic, transcriptomic and proteomic data from early-stage and chemo-refractory LUAC and identified three robust subsets of KRAS-mutan...

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Bibliografski detalji
Izdano u:Cancer Discov
Glavni autori: Skoulidis, Ferdinandos, Byers, Lauren A., Diao, Lixia, Papadimitrakopoulou, Vassiliki A., Tong, Pan, Izzo, Julie, Behrens, Carmen, Kadara, Humam, Parra, Edwin R., Canales, Jaime Rodriguez, Zhang, Jianjun, Giri, Uma, Gudikote, Jayanthi, Cortez, Maria A., Yang, Chao, Fan, You Hong, Peyton, Michael, Girard, Luc, Coombes, Kevin R., Toniatti, Carlo, Heffernan, Timothy P., Choi, Murim, Frampton, Garrett M., Miller, Vincent, Weinstein, John N., Herbst, Roy S., Wong, Kwok-Kin, Zhang, Jianhua, Sharma, Padmanee, Mills, Gordon B., Hong, Waun K., Minna, John D., Allison, James P., Futreal, Andrew, Wang, Jing, Wistuba, Ignacio I., Heymach, John V.
Format: Artigo
Jezik:Inglês
Izdano: 2015
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527963/
https://ncbi.nlm.nih.gov/pubmed/26069186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-14-1236
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