Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca(2+)-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets

Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca(2+)-mobilizing second messenger, cyclic ADP-ribose (cADPR). Here we show that a hybrid compound, arginine thiazolidine carboxylate (ATC), increases cytoplasm...

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Bibliographic Details
Published in:PLoS One
Main Authors: Park, Dae-Ryoung, Shawl, Asif Iqbal, Ha, Tae-Geun, Park, Kwang-Hyun, Kim, Seon-Young, Kim, Uh-Hyun
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527757/
https://ncbi.nlm.nih.gov/pubmed/26247205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134962
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