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Arginine Thiazolidine Carboxylate Stimulates Insulin Secretion through Production of Ca(2+)-Mobilizing Second Messengers NAADP and cADPR in Pancreatic Islets
Oxothiazolidine carboxylic acid is a prodrug of cysteine that acts as an anti-diabetic agent via insulin secretion and the formation of the Ca(2+)-mobilizing second messenger, cyclic ADP-ribose (cADPR). Here we show that a hybrid compound, arginine thiazolidine carboxylate (ATC), increases cytoplasm...
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| Udgivet i: | PLoS One |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4527757/ https://ncbi.nlm.nih.gov/pubmed/26247205 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0134962 |
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