A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a devastating, fatal neurological disease that primarily affects spinal cord anterior horn cells and their axons for which there is no treatment. Here we report the use of a recombinant natural human IgM that binds to the surface of neurons and supports neurite...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Xu, Xiaohua, Denic, Aleksandar, Jordan, Luke R., Wittenberg, Nathan J., Warrington, Arthur E., Wootla, Bharath, Papke, Louisa M., Zoecklein, Laurie J., Yoo, Daehan, Shaver, Jonah, Oh, Sang-Hyun, Pease, Larry R., Rodriguez, Moses
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527295/
https://ncbi.nlm.nih.gov/pubmed/26035393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.020727
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