Apoc2 loss-of-function zebrafish mutant as a genetic model of hyperlipidemia

Apolipoprotein C-II (APOC2) is an obligatory activator of lipoprotein lipase. Human patients with APOC2 deficiency display severe hypertriglyceridemia while consuming a normal diet, often manifesting xanthomas, lipemia retinalis and pancreatitis. Hypertriglyceridemia is also an important risk factor...

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Detalhes bibliográficos
Publicado no:Dis Model Mech
Main Authors: Liu, Chao, Gates, Keith P., Fang, Longhou, Amar, Marcelo J., Schneider, Dina A., Geng, Honglian, Huang, Wei, Kim, Jungsu, Pattison, Jennifer, Zhang, Jian, Witztum, Joseph L., Remaley, Alan T., Dong, P. Duc, Miller, Yury I.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2015
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Resource Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4527288/
https://ncbi.nlm.nih.gov/pubmed/26044956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019836
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