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Creation of Apolipoprotein C-II (ApoC-II) Mutant Mice and Correction of Their Hypertriglyceridemia with an ApoC-II Mimetic Peptide

Apolipoprotein C-II (apoC-II) is a cofactor for lipoprotein lipase, a plasma enzyme that hydrolyzes triglycerides (TGs). ApoC-II deficiency in humans results in hypertriglyceridemia. We used zinc finger nucleases to create Apoc2 mutant mice to investigate the use of C-II-a, a short apoC-II mimetic p...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Sakurai, Toshihiro, Sakurai, Akiko, Vaisman, Boris L., Amar, Marcelo J., Liu, Chengyu, Gordon, Scott M., Drake, Steven K., Pryor, Milton, Sampson, Maureen L., Yang, Ling, Freeman, Lita A., Remaley, Alan T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4727155/
https://ncbi.nlm.nih.gov/pubmed/26574515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.229740
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